Colorado Local Section

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"What do I do when..." - Navigating Day-to-Day Research Ethics - COACS Meeting - November 30, 2017 - CSU

“What do I do when….

“Navigating Day-to-Day Research Ethics

  Professor Ellen Fisher

Research Integrity Officer

Assistant Vice President for Strategic Initiatives

Professor, Department of Chemistry

Colorado State University

 

5:30 to 8:30 pm Friday,

November 30, 2017

 

Colorado State University

Lory Student Center, Grey Rock Room

 

ACS Members: $5                                  Students: free

 Event is subsidized by the COACS chair funds

Reservation Deadline: noon November 24


E-mail reservation information to Janet.Moder@colostate.edu

or call 970-491-5409

 Campus Map to the Lory Student Center

 The Grey Rock Room is up one flight of stairs/elevator on the north end of the building, close to the parking lot.

Abstract

Although researchers everywhere may agree on the big picture ethical norms in our scientific societies and communities, such as promoting the overarching aims of research, protecting intellectual property, giving credit for contributions and being accountable to the public, it is often difficult to understand how to address the day-to-day issues that arise in our scientific workplace.  This fun and interactive presentation will focus on distinguishing between what constitutes Misconduct in Science and just questionable research practices.  The latest in federal funding agency guidelines and the national conversation on responsible conduct of research will also be discussed.  Case studies will highlight practical navigation strategies for dealing with day-to-day issues as they arise or maybe even before they arise.

Driving & Parking Instructions

 

From Interstate 25:

•   Exit at Prospect Road (#268).

•   Travel west on Prospect approximately 4 miles to College Avenue (passing major intersections at Timberline Road and Lemay Avenue).

•   At College Avenue, turn right (north).

•   Continue north approximately three-quarters of a mile to Laurel

Street, turn left (west).

 

•   Travel west three-quarters of a mile to Meldrum and turn left into the Lory Student Center parking lot.

Parking:

Parking is available in the Lory Student Center parking lot via Pay to Park meters.  Pay to Park meters are enforced 7:30 am – 4:00 pm.  Please note that the A portion of the lots in these areas are enforced until 7 pm.  For full details and a map, please visit CSU’s parking information here.

 

 

The Dynamic Cell Surface: COACS Meeting - December 18

”The Dynamic Cell Surface”

 Professor George Barisas   

 

 Department of Chemistry Colorado State University

 December 18, 2017

 Colorado State University

Lory Student Center, Room 382


Social 11:30 a.m.         

        Lunch 12:00 p.m.       

                Program 1:00 p.m.

 ACS Members: $20                                  Students: $10

Reservation Deadline:  Monday, December 13

E-mail reservation information to Janet.Moder@colostate.edu or call 970-491-5409

 Campus Map to the Lory Student Center

  The Room 382 is up one flight of stairs/elevator on the north end of the building, close to the parking lot.


Abstract

That molecules in living cell surfaces are in constant motion and that this motion is physiologically significant is a relatively recent concept.  Semi-quantitative imaging studies by Mike Edidin in 1972 showed that proteins diffuse laterally in the plane of the cell membrane at a rate of approximately 1x10-10 cm2sec-1. Quantitating such motions was first attempted in 1974 by Reiner Peters and this approach is today called FRAP or fluorescence recovery after photobleaching.  In 1975 we began developing various implementations of this technique to examine diffusion of molecules in solution and on cell surfaces. These measurements allow estimating degrees of receptor aggregation by ligands such as antigens and hormones.  A common feature of several studies has been that modest degrees of receptor clustering lead to cell activation while more extensive crosslinking places cells in a refractory state.

However, lateral motions of molecules in two-dimensional environments such as cell surfaces are only weak functions of molecular size. Recognition of this led to interest in examining membrane protein rotation as a more sensitive probe of receptor clustering.  Protein rotation measurements are challenging since typical receptors rotate over times of perhaps 20-200 microseconds and techniques useful on this timescale such as transient absorption and time-resolved phosphorescence anisotropy dahave limited sensitivity. We developed fluorescence depletion anisotropy or FDA methods to extend that sensitivity and, for example, showed on individual cells that activation of Type I Fc­ε receptors responsible for allergy symptoms can arise from simple receptor dimer formation by allergen.

Many aspects of cell surface dynamics cannot be studied by ensemble measurements such as FRAP or FDA but rather require observation of single molecules. Lateral motions of individual molecules were first evaluated by differential interference contrast microscopy of cells with gold nanoparticle-labeled receptors and subsequently by fluorescence microscopy of cells where receptor labels are fluorescent quantum dots.  Such methods show that particular cell surface proteins are confined to cytoskeletally-defined 100 nanometer-scale regions within which they diffuse hydrodynamically at rates of 1x10-9 cm2sec-1.  Thus, what is actually observed, in most FRAP measurements is the “hopping” of receptors between such regions at rates between about 1x10‑10 and 1x10‑12 cm2sec-1.

We are currently exploring rotation of single cell surface molecules. Asymmetric quantum dots emit polarized fluorescence and the time-autocorrelation function of fluctuations in fluorescence anisotropy reflects molecular rotation or reorientation.  We find that various receptors exhibit slow orientational fluctuations on the 100-millisecond timescale and that these fluctuations are independent of treatments affecting receptor aggregation or the overall membrane environment.  This suggests that small, sub-micrometer membrane regions may liberate with respect to the overall cell surface.  This would represent a new aspect of membrane dynamics not considered previously.  Our long-term goal is to extend single-molecule rotation measurements into the microsecond timescale of membrane protein hydrodynamic motion.

Driving & Parking Instructions

 From Interstate 25:

•   Exit at Prospect Road (#268).

•   Travel west on Prospect approximately 4 miles to College Avenue (passing major intersections at Timberline Road and Lemay Avenue).

•   At College Avenue, turn right (north).

•   Continue north approximately three-quarters of a mile to Laurel

Street, turn left (west).

 •   Travel west three-quarters of a mile to Meldrum and turn left into the Lory Student Center parking lot.

 Parking:

Parking is available in the Lory Student Center parking lot via Pay to Park meters.  Pay to Park meters are enforced 7:30 am – 4:00 pm.  Please note that the A portion of the lots in these areas are enforced until 7 pm.  For full details and a map, please visit CSU’s parking information here.

Calendar of Upcoming Events - work in progress

Upcoming ACS Events (most in the planning stage)

ACS Rocky Mountain Regional Meeting (RMRM) – Oct 25th – 28th   Loveland, CO   rmrm2017.sites.acs.org 

2nd Monday of the month, October 2017 thru May 2018, Boulder Café Scientifique at Bohemian Biergarten, Pearl Street Mall, Boulder – jointly sponsored with CU Sigma Xi

In Planning Stage:

Fall Monthly ACS Meeting                   potential western slope location TBA

January Monthly Event                        to celebrate ACS Service Award Winners

February Monthly Event                      TBA

March Monthly Event                           TBA

April Monthly Event                              Teacher/Student  Awards Dinner jointly sponsored with                                                                CCTA to honor Colorado’s brightest High School                                                                           students and their teachers

Summer:                                               Senior Meetings 

May 5th-7th Strategic Planning Retreat Results

Thank you so much for supporting your Colorado ACS local section by completing the         survey a few weeks back.

The Strategic Planning Committee with your help devised 4 goals

    Your words were transformed into goals!    for  Strategic Planning Goals Preview 

Want to become more involved? Help-out with strategies and implementation?  Want to receive email notices about monthly events from your COACS? Want to Volunteer to help grow our section?
  
contact sandra.bonetti@csupueblo.edu         

We are planning and hosting the Rocky Mountain Regional Meeting this fall in Loveland, Colorado, Oct. 25-28, rmrm2017.sites.acs.org     Abstract submission is open.

http://acscolorado.sites.acs.org  2017 Strategic Plan & Calendar of Upcoming Events to be posted

                                                                                                                                                                       

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